He generally saved his sarcasm for people who didn't drill holes in his bones with very expensive and very sharp instruments.

Yet more evidence Mycroft is smarter than everyone else.

It could have had something to do with the fact that he intensely disliked the feeling of being on the other side of the magnifier.

Deceptively simple statement, really perceptive!

He certainly did not grimace at that, but the good doctor stopped all the same.

Ow, ow, ow! Well done!